Leonard, Sheldon, Howard, Raj, Amy, and Bernadette are invited to participate on a science panel at the Institute of Interdisciplinary Study symposium on “The Impact of Current Scientific Research on Societal Interactions ” in San Francisco.
The following morning, Sheldon opens the Science& Society panel with a poorly-received joke. Bernadette is asked to speak next; on a mic, she subtly hints that even Howard’s penis size can pleasure her by saying “It’s not just giant nuclear weapon can destroy the world, as a microbiologist I can tell you that even the tiniest micro-organism can tear you a new one .” Howard then replies, “Though she claims her field of interest is micro-organism, she has spent her fair share of time around what we can presume is pretty massive weaponry .” Bernadette then says she can get all the giant missiles she wants. Amy then asks whether they are talking about a woman wanting penises. Raj clearly intoxicated then adds that he thinks they are talking about penises and that the mimosas are kicking his “little brown ass “.
Leonard says he would like to kicking Raj’s “little brown ass ” and explains he is still upset about Raj interrupting his chance to get back with Penny. Penny rapidly clarifies that it was just a hook-up, and they weren’t getting back together. Despite the hysteria, Sheldon tries to bring the topic back to center but fails. As Howard and Bernadette continue their petty feud, Sheldon opens the audience to Q& A. Penny publicly asks if anybody can drive her back to Los Angeles. Glenn agrees to drive her; as Leonard considers Glenn’s height he is quickly threatened and screams out.